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KMID : 0604519960220020174
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Journal of the Society of Cosmetic Scientists of Korea
1996 Volume.22 No. 2 p.174 ~ p.181
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The Synthesis and Sfety of 3-Aminopropyl dihydrogen phosphate, a New Anti-aging Agent.
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Pyun, Young Hoon
Ko, Jae Sook,Cho, Yoon Gi/Cheon, Ji Min/Lee, Bo Seaub
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Abstract
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The novel synthesis of 3-aminopropyl dihydrogen phosph opropaphosphoric acid), and its applicability to the skin as a cosr terms of its efficacy and toxicology were presented.
The phosphorylation of 3-amino-1-propanol was carried out via cyclization into 6-membered 2,6-oxaza-phosphoryl ring in the presence of phosphorous oxychloride and an organic base. The subsequent ring-opening hydrolysis and crystallization afforded the highly purified product in 90% isoloated yield. The method is much superior to the previous literature phosphorylation methods, as the procedure is simple and high-yielding.
To confirm the efficacy of 3-APPA, several activities related to anti-aging capacity were measured. In-vitro human fibroblast, linear and 3-dimensional collagen matrix culture revealed that 3-APPA stimulated the proliferation of fibroblasts, and enhanced the synthesis of collagen, which showed 3-APPA´s potency for skin wrinkle reduction.
The toxicological aspect of 3-APPA was also extensively examined. In vivo toxicity tests such as acute oral toxicity, eye irritation, human patch, and the repeat insult human patch test proved 3-APPA to be a safe material.
Thus 3-APPA can be used as an effective anti-aging agent for various cosmetic formulations.
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